Low pH Exposure During Immunoglobulin G Purification Methods Results in Aggregates That Avidly Bind Fcγ Receptors: Implications for Measuring Fc Dependent Antibody Functions.

Low pH Exposure During Immunoglobulin G Purification Methods Results in Aggregates That Avidly Bind Fcγ Receptors: Implications for Measuring Fc Dependent Antibody Functions.

Evaluating the biophysical and practical nature of IgG is essential to defining correlates of safety in infectious illness, and autoimmunity analysis cohorts, in addition to vaccine efficacy trials. These research typically require small portions of IgG to be purified from plasma for downstream evaluation with excessive throughput immunoaffinity codecs which elute IgG at low-pH, resembling … Read more Low pH Exposure During Immunoglobulin G Purification Methods Results in Aggregates That Avidly Bind Fcγ Receptors: Implications for Measuring Fc Dependent Antibody Functions.